周广玺-济宁医学院附属医院

Ø 基本情况介绍：周广玺，女，济宁医学院附属医院消化内科二病区副主任，主任医师，医学博士，博士后合作导师，泰山学者青年专家。2017.07毕业于同济大学。Ø 研究方向：肠道免疫性疾病的临床与基础研究。Ø 研究生培养：目前培养硕士研究生6人。Ø 近三年承担科研课题：1. 国家自然科学基金面上项目，82270562，中性粒细胞表达的DAP12在炎症性肠病肠黏膜损伤发生过程中的免疫机制研究，2023/01-2026/12，52万元，在研，负责人。2. 山东省泰山学者（青年专家）人才项目，tsqn202103190，新型CD4+ T细胞亚群对炎症性肠病的免疫调控机制及靶向治疗转化应用研究，2021.01-2025.12，50万元，在研，负责人。3. 济宁医学院高层次科研项目培育计划，JYGC2021FKJ003，IRF5在炎症性肠病肠黏膜炎症及炎癌转化过程中的免疫生物学研究，2022.01-2024.12，10万元，在研，负责人。4. 济宁医学院贺林院士新医学临床转化工作站科研基金，重点项目，JYHL2022FZD05，巨噬细胞表达的Syk对溃疡性结肠炎CD4+ T细胞免疫应答反应的调控作用及其分子作用机制，2023.01-2025.12，20万元，在研，负责人。5. 济宁市重点研发计划，2021YXNS045，CD73对炎症性肠病巨噬细胞分化的免疫调控机制研究，2021.12-2023.12，在研，负责人。Ø 近三年发表的主要论文：1. Leilei Chen,Yan Wang,Huihui Zhou,Yi Liang,Fengqin Zhu,Guangxi Zhou. The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease. Precis Clin Med, 2024.2. Fengqin Zhu, Dehuai Jing,Huihui Zhou, Zongjing Hu, Yan Wang, Guiyuan Jin, Yonghong Yang, Guangxi Zhou. Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis. Precis Clin Med, 2023;6(4):pbad025. 3. Fengqin Zhu, Zongjing Hu, Wei Yu, Fengxian Dai, Dehuai Jing, Guangxi Zhou. Ulcerative Colitis Concomitant with Cytomegalovirus Infection, Bullous Sweet's Syndrome, and Acute Myeloid Leukemia: A Case Report and Literature Review. J Inflamm Res,2023 Aug 28:16:3715-3723. 4. Yaqi Zhou, Yaowen Zhang, Wei Yu, Yufen Qin, Heng He, Fengxian Dai, Yibo Wang, Fengqin Zhu, Guangxi Zhou. Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases. Immun Inflamm Dis,2023 Jul;11(7):e934. 5. Guangxi Zhou, Fengqin Zhu, Hairong Zhang, Yan Wang, Yonghong Yang, Guiyuan Jin, Yibo Wang, Guanjun Dong, Huabao Xiong. PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis. FASEB J,2023 Jul;37(7):e22967. 6. Ru Wang, Yan Wang, Chao Wu, Guiyuan Jin, Fengqin Zhu, Yonghong Yang, Yibo Wang, Guangxi Zhou. CD73 blockade alleviates intestinal inflammatory responses by regulating macrophage differentiation in ulcerative colitis. Exp Ther Med,2023 Apr 21;25(6):272. 7. Yaqi Zhou, Fengqin Zhu, Dehuai Jing, Quanyi Wang, Guangxi Zhou. Ulcerative colitis and thrombocytosis: Case report and literature review. Medicine (Baltimore),2023 May 19;102(20):e33784. (IF=1.6) 3区8. Xixi Bian, Honglu Xue, Dehuai Jing, Yan Wang, Guangxi Zhou, Fengqin Zhu.  Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases. Inflammation, 2023 Jun 24. 9. Guangxi Zhou#, Fei Hou, Heng He, Yuan Xue, Yibo Wang, Xueying Chen, Fengqin Zhu*, Myocyte Enhancer Factor 2A Contributes to the TGF-β1-Mediated Cholangiocyte Epithelial to Mesenchymal Transition and Senescence in Cholestatic Liver Fibrosis. Front Biosci (Landmark Ed), 2022; 27(12):324. 10. Fengqin Zhu, Yufen Qin, Yan Wang, Fan Zhang, Zhen Xu, Fengxian Dai, Wenjuan Chu, Yibo Wang, Guangxi Zhou*. Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis. Eur J Gastroenterol Hepatol, 2022;34(10):993-999. 11. Dehuai Jing, Fengqin Zhu, Zhen Xu, Guifang Zhang, Guangxi Zhou*. The role of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in immune diseases. Transpl Immunol, 2022. 12. Hairong Zhang#, Cuimei Ma, Yuan Xue , Zongjing Hu, Zhen Xu, Yibo Wang, Guangxi Zhou*, A case report about eosinophilic enteritis presenting as abdominal pain，Medicine, 2021,100(39):e27296. 13. Guanjun Dong#, Yonghong Yang, Hairong Zhang, Wei Yu, Heng He, Fengxian Dai, Cuimei Ma, Yibo Wang, Fengqin Zhu, Huabao Xiong, Guangxi Zhou*, Protein Kinase CK2 Maintains Reciprocal Balance Between Th17 and Treg Cells in the Pathogenesis of UC. Inflamm Bowel Dis. 2022, 28(6):830-842. 14. Guangxi Zhou#, Huili Wu#, Jian Lin, Ritian Lin, Baisui Feng, Zhanju Liu*, TRIM21 Is Decreased in Colitis-Associated Cancer and Negatively Regulates Epithelial Carcinogenesis, Inflamm Bowel Dis, 2021, 27(4):458-468. Ø 获奖情况：山东省研究生创新成果奖Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.  指导教师：朱凤琴、周广玺